RPSA : ribosomal protein SA
Description
The RPSA (ribosomal protein SA) is a protein-coding gene located on chromosome 3.
The RPSA gene provides instructions for making a protein called ribosomal protein SA, which is one of approximately 80 different ribosomal proteins. These proteins come together to form structures called ribosomes. Ribosomes process the cell's genetic instructions to create proteins. Each ribosome is made up of two parts (subunits) called the large subunit and the small subunit. Ribosomal protein SA is part of the small subunit. The specific roles of each of the ribosomal proteins within the ribosome are not entirely understood. Some ribosomal proteins are involved in the assembly or stability of ribosomes. Others help carry out the ribosome's main function of building new proteins. Research suggests that ribosomal protein SA helps the ribosome control the production of certain proteins, many of which are likely important for development before birth.
RPSA is essential for the assembly and stability of the 40S ribosomal subunit. It plays a crucial role in the maturation of ribosomal subunits by facilitating the processing of the 20S rRNA precursor into mature 18S rRNA. Beyond its ribosomal function, RPSA also acts as a cell surface receptor for laminin, contributing to cell adhesion to the basement membrane and subsequent activation of signaling pathways. This interaction might be involved in cell fate determination and tissue morphogenesis. Additionally, RPSA serves as a substrate for the protein phosphatase 1 catalytic subunit alpha (PPP1CA) in a manner dependent on the regulatory subunit PPP1R16B.
RPSA is also known as 37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40, uS2.
