RPS27
Description
The RPS27 (ribosomal protein S27) is a protein-coding gene located on chromosome 1.
RPS27 (Ribosomal Protein S27) is a protein involved in protein synthesis. It is a component of the small ribosomal subunit (40S) and belongs to the S27E family of ribosomal proteins. RPS27 has a C4-type zinc finger domain that binds zinc. RPS27 can bind to nucleic acid and is primarily located in the cytoplasm as part of the ribosome. However, it has also been detected in the nucleus. RPS27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. RPS27 is proposed to be involved in DNA repair and oncogenesis. It is also known as Metallopan-stimulin 1 (MPS-1).
RPS27 is a component of the small ribosomal subunit (40S) and is involved in protein synthesis (PubMed:23636399, PubMed:8706699). It is essential for the proper processing and maturation of 18S ribosomal RNA (rRNA) (PubMed:25424902). RPS27 is part of the small subunit (SSU) processome, which is the precursor of the small eukaryotic ribosomal subunit. The SSU processome assembles in the nucleolus, where various factors, including ribosome biogenesis factors, RNA chaperones, and ribosomal proteins, interact with the nascent pre-rRNA. These factors work together to ensure proper RNA folding, modification, rearrangement, cleavage, and degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
RPS27 is also known as DBA17, MPS-1, MPS1, S27, eS27.
