RNF31
Description
The RNF31 (ring finger protein 31) is a protein-coding gene located on chromosome 14.
RNF31 is a human gene that encodes a protein containing a RING finger domain. This motif is known to be involved in protein-DNA and protein-protein interactions. The RNF31 protein is an E3 ubiquitin-protein ligase, a type of enzyme that attaches ubiquitin molecules to target proteins.
RNF31 is a critical component of the LUBAC complex, which plays a crucial role in regulating inflammation and immune responses. LUBAC is responsible for attaching linear ubiquitin chains to target proteins, including IKBKG and RIPK1, which activates the NF-κB and JNK signaling pathways. This linear ubiquitination process inhibits TNF-induced cell death, preventing excessive inflammation. LUBAC is recruited to the TNF-R1 signaling complex upon polyubiquitination by BIRC2 and/or BIRC3, stabilizing the complex and contributing to NF-κB activation. Additionally, LUBAC is involved in innate immunity by forming a ubiquitin coat on bacteria invading the cytosol, promoting their degradation by xenophagy and activating NF-κB. The complex also regulates the canonical Wnt signaling pathway during angiogenesis. RNF31 specifically mediates the linear ubiquitination of BCL10, promoting TCR-induced NF-κB activation. It can bind to polyubiquitin chains with various linkages. LUBAC's activity is tightly regulated by OTULIN, which removes linear ubiquitin chains.
RNF31 is also known as HOIP, IMD115, Paul, ZIBRA.
