FOXI3
Description
The FOXI3 (forkhead box I3) is a protein-coding gene located on chromosome 2.
FOXI3 (Forkhead box I3) is a protein encoded by the FOXI3 gene in humans. It's a forkhead box transcription factor involved in hair and teeth development. A mutation in FOXI3 is responsible for the Hh hairless trait in dogs, a dominant allele expressed in heterozygotes. FOXI3 was identified in 2008.
FOXI3 is a transcription factor that plays a crucial role in pharyngeal arch development. It influences the development of various structures, including hair, ears, jaw, and teeth (PubMed:37041148). It may act as a pioneer transcription factor during pharyngeal arch development (By similarity). FOXI3 is essential for epithelial cell differentiation within the epidermis (By similarity). It participates in multiple stages of otic placode induction, ensuring the preplacodal ectoderm properly develops into the inner ear (By similarity). This gene is required for hair follicle stem cell specification (By similarity). Furthermore, FOXI3 acts downstream of TBX1 to facilitate the formation of the thymus and parathyroid glands from the third pharyngeal pouch (By similarity). {ECO:0000250|UniProtKB:D3Z120, ECO:0000269|PubMed:37041148}
FOXI3 is also known as CFM2.
