CXCR2
Description
The CXCR2 (C-X-C motif chemokine receptor 2) is a protein-coding gene located on chromosome 2.
CXCR2, also known as IL8RB, is a chemokine receptor belonging to the G-protein-coupled receptor family. It binds to IL-8 with high affinity, triggering a signal transduction cascade through a Gi/o-coupled G-protein-activated second messenger system. CXCR2 also binds to CXCL1 (MGSA), a melanoma growth stimulating protein, and is crucial for serum-dependent melanoma cell growth. Additionally, it binds to CXCL2, CXCL3, and CXCL5. CXCR2 mediates the angiogenic effects of IL-8 in intestinal microvascular endothelial cells. Studies in knockout mice suggest that CXCR2 regulates the positioning of oligodendrocyte precursors in the developing spinal cord by inhibiting their migration. CXCR2, along with IL8RA (another high affinity IL8 receptor), and IL8RBP (a pseudogene of IL8RB), are clustered in a region on chromosome 2q33-q36.
CXCR2 is a receptor for interleukin-8 (IL-8), a potent neutrophil chemotactic factor. Binding of IL-8 to CXCR2 activates neutrophils through a G-protein coupled pathway, leading to activation of a phosphatidylinositol-calcium second messenger system. CXCR2 binds to IL-8 with high affinity and also interacts with CXCL3, GRO/MGSA and NAP-2.
CXCR2 is also known as CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, WHIMS2.
