ANKZF1
Description
The ANKZF1 (ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1) is a protein-coding gene located on chromosome 2.
ANKZF1 is a protein encoded by the ANKZF1 gene in humans. It contains ankyrin repeat and zinc finger domains.
ANKZF1 is an endonuclease that acts downstream of the ribosome-associated quality control (RQC) pathway. It cleaves polypeptidyl-tRNAs, releasing incompletely synthesized polypeptides for degradation. This process is part of the RQC pathway which disassembles stalled translation complexes and recycles or degrades their components. ANKZF1 specifically removes the terminal 3'-CCA nucleotides from polypeptidyl-tRNAs, releasing ubiquitinated polypeptides for degradation and cleaved tRNAs. The cleaved tRNAs are then repaired and recycled by ELAC1 and TRNT1. ANKZF1 also contributes to the cellular response to hydrogen peroxide and maintains mitochondrial integrity under stress conditions.
ANKZF1 is also known as Vms1, ZNF744.
Associated Diseases
- lysosomal storage disease
- Parkinson disease
- multiple sclerosis
- Alzheimer disease
- nonpapillary renal cell carcinoma
- glioblastoma
- cancer
