XRCC2

Description

XRCC2, or X-ray repair cross-complementing group 2, is a crucial gene involved in the crucial process of homologous recombination (HR), a vital DNA repair pathway. HR effectively mends double-strand DNA breaks, which are particularly damaging lesions often caused by radiation and other environmental stressors. This repair mechanism is crucial for maintaining the integrity of the genome and preventing cell death or uncontrolled proliferation, which can lead to cancer. The XRCC2 gene encodes a protein that interacts with other proteins within the HR pathway, forming a complex responsible for recognizing and processing DNA damage. This intricate dance of proteins ensures accurate and efficient repair, safeguarding the genetic blueprint of life.

Associated Diseases

• Cancer predisposition, particularly breast, ovarian, and pancreatic cancers
• Increased sensitivity to radiation
• Defective DNA repair syndromes, such as Fanconi anemia

Did you know?

Mutations in XRCC2 have been linked to an increased risk of developing certain cancers, highlighting its role in maintaining genomic stability.