TONSL
Description
The TONSL (tonsoku like, DNA repair protein) is a protein-coding gene located on chromosome 8.
The TONSL gene encodes a protein involved in regulating NF-kappa-B mediated transcription. This protein may act as a negative regulator by binding to NF-kappa-B complexes, preventing their entry into the nucleus and interaction with DNA. Phosphorylation of the protein targets it for degradation via the ubiquitination pathway, releasing NF-kappa-B complexes to enter the nucleus.
The TONSL protein is a component of the MMS22L-TONSL complex, which plays a crucial role in DNA repair by promoting homologous recombination. This complex is essential for maintaining genome integrity during DNA replication. It recognizes and binds newly synthesized histones, specifically H4K20me0 and H3.1, facilitating the recruitment of RAD51 filaments to double-strand breaks (DSBs) at stalled or collapsed replication forks. This process is vital for repairing DSBs, ensuring proper DNA replication and preventing genome instability.
TONSL is also known as IKBR, NFKBIL2, SEMDSP.
