SLC25A38

Description

SLC25A38, also known as the mitochondrial dicarboxylate carrier, is a gene that encodes a protein responsible for transporting dicarboxylates across the inner mitochondrial membrane. These dicarboxylates, such as malate and succinate, are crucial intermediates in the citric acid cycle and other metabolic pathways. The SLC25A38 protein plays a vital role in maintaining mitochondrial function and energy production.

Associated Diseases

• Mitochondrial diseases: Mutations in SLC25A38 have been linked to a range of mitochondrial disorders, including Leigh syndrome and mitochondrial encephalomyopathy.
• Cancer: Some studies suggest a possible association between SLC25A38 gene variants and cancer susceptibility, particularly in certain types of cancers.

Did you know?

The SLC25A38 gene is highly conserved across different species, highlighting its fundamental role in cellular metabolism.