SEC23B : SEC23 homolog B, COPII coat complex component
Description
The SEC23B (SEC23 homolog B, COPII coat complex component) is a protein-coding gene located on chromosome 20.
The SEC23B gene provides instructions for making a component of a large group of interacting proteins called coat protein complex II (COPII). COPII is involved in the formation of vesicles, small sac-like structures that transport proteins and other materials within cells. Specifically, COPII triggers the formation of vesicles in a cellular structure called the endoplasmic reticulum (ER), which is involved in protein processing and transport. These COPII vesicles carry proteins that are destined to be exported out of cells (secreted). The SEC23B protein is very similar to the protein produced from a related gene, SEC23A. These proteins are both components of COPII, and they appear to have overlapping functions. In most types of cells, if one of these proteins is missing, the other may be able to compensate for the loss. However, research indicates that the SEC23B protein may have a unique function in developing red blood cells (erythroblasts).
SEC23B is a component of the coat protein complex II (COPII), which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). COPII has two main functions: physically deforming the ER membrane into vesicles and selecting cargo molecules for transport to the Golgi complex.
SEC23B is also known as CDA-II, CDAII, CDAN2, CWS7, HEMPAS, hSec23B.
Associated Diseases
- Cowden syndrome 7
- Anemia, dyserythropoietic congenital, type II
- Cowden syndrome
- Congenital dyserythropoietic anemia
