RASGRP2
Description
The RASGRP2 (RAS guanyl releasing protein 2) is a protein-coding gene located on chromosome 11.
RASGRP2, the gene encoding RAS guanyl-releasing protein 2, is highly expressed in the brain. The protein it produces acts as a nucleotide exchange factor, activating small GTPases such as RAS and RAP1/RAS3. Its activity is enhanced by calcium and diacylglycerol. Two different versions of the protein are produced through alternative splicing. Mutations in RASGRP2 are linked to severe bleeding.
RASGRP2 acts as a calcium- and DAG-regulated nucleotide exchange factor, primarily activating Rap by facilitating the exchange of GDP for GTP. It also has the potential to activate other GTPases, including RRAS, RRAS2, NRAS, and KRAS, but not HRAS. RASGRP2 plays a role in platelet aggregation and adhesion of T-lymphocytes and neutrophils, likely through inside-out integrin activation. It may also function within the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
RASGRP2 is also known as CALDAG-GEFI, CDC25L.
