PLVAP
Description
The PLVAP (plasmalemma vesicle associated protein) is a protein-coding gene located on chromosome 19.
Plasmalemma vesicle-associated protein is a protein that in humans is encoded by the PLVAP gene.
PLVAP is a membrane protein specifically found in endothelial cells. It plays a crucial role in the formation of diaphragms, which bridge endothelial fenestrae, and is also essential for the formation of caveolae stomata and transendothelial channels. This protein contributes to microvascular permeability, allowing for the passage of water and solutes through endothelial fenestrae. PLVAP also regulates the balance between transcellular and paracellular flow in various organs. Notably, it plays a significant role in embryonic development.
PLVAP is also known as DIAR10, FELS, PV-1, PV1, gp68.
