NCF2 : neutrophil cytosolic factor 2
Description
The NCF2 (neutrophil cytosolic factor 2) is a protein-coding gene located on chromosome 1.
The NCF2 gene provides instructions for making a protein called neutrophil cytosolic factor 2 (also known as p67-phox). This protein is part of a group of proteins that forms an enzyme complex called NADPH oxidase, which is essential for the immune system. NADPH oxidase is primarily active in phagocytes, immune system cells that destroy foreign invaders like bacteria and fungi. NADPH oxidase is also thought to regulate neutrophils, which adjust the inflammatory response for optimal healing. Foreign invaders stimulate phagocytes, triggering NADPH oxidase assembly. This enzyme converts oxygen into superoxide, a toxic molecule, which generates other compounds, such as hydrogen peroxide (a disinfectant) and hypochlorous acid (bleach). These highly reactive substances, known as reactive oxygen species, are used by phagocytes to kill invaders, preventing them from reproducing and causing illness.
NCF2 is also known as NCF-2, NOXA2, P67-PHOX, P67PHOX.
Associated Diseases
- Granulomatous disease, chronic, autosomal recessive, cytochrome b-positive, type II
- Chronic granulomatous disease
- Systemic lupus erythematosus
