HMOX1
Description
The HMOX1 gene encodes heme oxygenase-1 (HO-1), an enzyme crucial for heme degradation. HO-1 catalyzes the breakdown of heme into biliverdin, free iron, and carbon monoxide. This process is essential for maintaining cellular homeostasis by removing harmful heme, preventing oxidative stress, and promoting antioxidant defenses. HO-1 exhibits anti-inflammatory and cytoprotective properties, making it a significant player in various physiological and pathological processes.
Associated Diseases
- Atherosclerosis
- Cancer
- Diabetes
- Neurodegenerative diseases (Alzheimer‘s disease, Parkinson‘s disease)
- Inflammation
- Ischemic stroke
- Kidney disease
- Liver disease
- Lung disease
- Sepsis
Did you know?
HO-1 is induced by various stimuli, including oxidative stress, inflammation, and heavy metals. This inducibility makes it a promising therapeutic target for various diseases.
