FLI1 : Fli-1 proto-oncogene, ETS transcription factor
Description
The FLI1 (Fli-1 proto-oncogene, ETS transcription factor) is a protein-coding gene located on chromosome 11.
The FLI1 gene provides instructions for making the FLI protein, which controls the activity (transcription) of genes. Transcription is the first step in the process of producing proteins. The FLI protein is part of a group of related proteins, called the Ets family of transcription factors, that control transcription. The FLI protein attaches (binds) to certain regions of DNA and turns on (activates) the transcription of nearby genes. The proteins produced from these genes control many important cellular processes, such as cell growth and division (proliferation), maturation (differentiation), and survival. The FLI protein is found primarily in blood cells and is thought to regulate their development.
FLI1 is a sequence-specific transcriptional activator that recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
FLI1 is also known as BDPLT21, EWSR2, FLI-1, SIC-1.
Associated Diseases
- Paris-Trousseau thrombocytopenia
- Peripheral primitive neuroectodermal tumor
- Jacobsen syndrome
- Bleeding disorder, platelet-type, 21
- Ewing sarcoma
