F12 : coagulation factor XII
Description
The F12 gene, located on chromosome 5, provides instructions for making a protein called Hageman factor (also known as factor XII). This protein is a crucial component of the intrinsic coagulation pathway, which plays a vital role in the formation of blood clots. When a blood vessel is damaged, Hageman factor initiates a complex cascade of events leading to the activation of other clotting factors, ultimately resulting in the formation of a fibrin clot to stop bleeding. Mutations in the F12 gene can disrupt this process, causing various bleeding disorders.
Associated Diseases
Did you know?
Hageman factor was discovered by John Hageman in 1955, who was a patient with a rare bleeding disorder.
