EIF2AK3
Description
The EIF2AK3 gene, also known as PKR (protein kinase R), plays a crucial role in regulating protein synthesis and cellular stress responses. It encodes a serine/threonine protein kinase that is activated in response to viral infection, double-stranded RNA, and other stressors. PKR phosphorylation of the translation initiation factor eIF2α inhibits protein synthesis, effectively halting viral replication and promoting cell survival. This intricate mechanism underscores the importance of EIF2AK3 in maintaining cellular homeostasis and fighting off viral infections.
Associated Diseases
- Viral Infections: PKR plays a vital role in antiviral immunity by inhibiting viral replication.
- Neurological Disorders: Mutations in EIF2AK3 have been linked to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and Alzheimer‘s disease.
- Cancer: PKR activity has been implicated in cancer progression and resistance to chemotherapy.
Did you know?
PKR was initially discovered as a cellular protein that could bind and be activated by double-stranded RNA, a hallmark of viral replication.
