CORO1A
Description
The CORO1A (coronin 1A) is a protein-coding gene located on chromosome 16.
Coronin-1A is a protein encoded by the CORO1A gene in humans. It plays a role in both T-cell mediated immunity and mitochondrial apoptosis. A recent genome-wide longevity study found that its expression levels were negatively correlated with age at blood sample collection and survival time after blood draw. The coronin protein family was discovered in 1991 using a cytoskeletal preparation called the "contracted propeller." This method helped isolate cytoskeletal proteins, including Coronin-1A, which was named for its crown-like shape when interacting with the cell surface. It has been extensively studied due to its complex structure and intriguing components. Research has shown that Coronin-1A acts as an actin binding facilitator in the presence of K-glutamate, mimicking the cellular environment.
Coro1A is a key component of the cytoskeleton in highly mobile cells. It contributes to both the inward folding of large sections of the cell membrane (invagination) and the outward extensions of the cell membrane (protrusions) that facilitate cell movement. In cells infected with Mycobacteria, Coro1A's presence on the phagosomal membrane prevents the merging of phagosomes with lysosomes.
CORO1A is also known as CLABP, CLIPINA, HCORO1, IMD8, TACO, p57.
