CD3G
Description
The CD3G gene encodes a subunit of the CD3 complex, a crucial component of the T cell receptor (TCR) complex. This complex plays a central role in T cell activation and signaling, mediating the recognition of antigen presented by antigen-presenting cells (APCs). CD3G, along with other CD3 subunits (CD3D, CD3E, CD3γ, and CD3δ), forms a heteromeric complex that associates with the TCR αβ heterodimer. This interaction is essential for TCR signaling, which initiates a cascade of events leading to T cell proliferation, differentiation, and effector functions. Mutations in the CD3G gene can disrupt TCR signaling, resulting in various immunodeficiency disorders.
Associated Diseases
Did you know?
CD3G is highly expressed on mature T cells, but is absent from other immune cells.
