BCL10
Description
BCL10, also known as B-cell lymphoma 10, is a protein-coding gene crucial for the regulation of immune cell signaling. Its protein product plays a critical role in activating NF-κB, a transcription factor central to immune and inflammatory responses. BCL10 interacts with various proteins, including CARMA3 and MALT1, forming a complex that triggers NF-κB activation upon cell stimulation. This intricate interplay regulates the expression of genes involved in immune responses, inflammation, and cell survival. Dysregulation of BCL10 function is linked to various immune disorders and cancers.
Associated Diseases
- MALT lymphoma
- Diffuse large B-cell lymphoma
- Hodgkin lymphoma
- Multiple myeloma
- Chronic lymphocytic leukemia
- Primary Sjögren‘s syndrome
- Systemic lupus erythematosus
- Crohn‘s disease
- Inflammatory bowel disease
- Autoimmune disorders
- Inflammatory diseases
Did you know?
BCL10 was initially identified as a gene overexpressed in mucosa-associated lymphoid tissue (MALT) lymphoma, a type of cancer affecting the digestive tract.
