ILDR2
Description
The ILDR2 (immunoglobulin like domain containing receptor 2) is a protein-coding gene located on chromosome 1.
ILDR2 is implicated in various cellular processes, including ER stress response, lipid homeostasis, and insulin secretion. It contributes to epithelial barrier function alongside ILDR1 and LSR by recruiting MARVELD2/tricellulin to tricellular tight junctions. As a B7-like protein, ILDR2 is expressed on immune cells and inflamed tissues, exhibiting T-cell inhibitory activity. Additionally, in the inner ear, ILDR2 potentially regulates alternative pre-mRNA splicing through interactions with TRA2A, TRA2B, and SRSF1.
ILDR2 is also known as C1orf32, dJ782G3.1.
Associated Diseases
- exercise-induced hyperinsulinism
- hyperinsulinism due to INSR deficiency
- glycogen storage disorder due to hepatic glycogen synthase deficiency
- hyperinsulinemic hypoglycemia, familial, 2
- 3-hydroxy-3-methylglutaryl-CoA synthase deficiency
- islet cell adenomatosis
- hyperinsulinemic hypoglycemia, familial, 1
- renal cysts and diabetes syndrome
