IL4
Description
The IL4 (interleukin 4) is a protein-coding gene located on chromosome 5.
IL4, Il-4, or IL-4 may refer to:
IL4 is a cytokine primarily secreted by mast cells, T-cells, eosinophils, and basophils, playing a crucial role in regulating antibody production, hematopoiesis, inflammation, and the development of effector T-cell responses. It induces the expression of class II MHC molecules on resting B-cells and enhances both secretion and cell surface expression of IgE and IgG1. IL4 also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes, positively regulates IL31RA expression in macrophages, and stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. Furthermore, IL4 plays a vital role in higher brain functions, such as memory and learning. Upon binding to IL4, the IL4R receptor dimerizes with either the common IL2R gamma chain/IL2RG to form the type 1 signaling complex, mainly located on hematopoietic cells, or with IL13RA1 to produce the type 2 complex, expressed on both hematopoietic and nonhematopoietic cells. Engagement of both receptor types initiates JAK3 and, to a lesser extent, JAK1 phosphorylation, leading to the activation of the signal transducer and activator of transcription 6/STAT6. IL4 interacts with IL4R and IL13RA1.
IL4 is also known as BCGF-1, BCGF1, BSF-1, BSF1, IL-4.
