IL3RA
Description
The IL3RA (interleukin 3 receptor subunit alpha) is a protein-coding gene located on chromosome X|Y.
IL3RA, also known as CD123, is a gene that encodes the alpha subunit of the interleukin 3 receptor. This receptor is involved in the regulation of hematopoiesis, the process by which blood cells are produced. The receptor is composed of two subunits: a ligand-specific alpha subunit (IL3RA) and a signal-transducing beta subunit (IL3RB). The alpha subunit binds to interleukin 3 (IL3), a cytokine that stimulates the production of blood cells. The beta subunit is shared by the receptors for IL3, colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of IL3 to IL3RA triggers a signaling cascade that activates the beta subunit and leads to the production of blood cells. IL3RA is expressed on hematopoietic progenitor cells, monocytes, and B-lymphocytes.
IL3RA is a cell surface receptor that binds to the cytokine interleukin-3 (IL3). It is expressed on hematopoietic progenitor cells, monocytes, and B-lymphocytes. Upon binding to IL3, IL3RA undergoes a conformational change that leads to the recruitment of the beta subunit (IL3RB). This heterodimerization triggers a signaling cascade involving the phosphorylation of JAK2 and PI3K, which in turn promotes cell proliferation and differentiation. Activation of JAK2 also leads to the activation of STAT5, a transcription factor that regulates gene expression involved in hematopoiesis.
IL3RA is also known as CD123, IL-3R-alpha, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra.
