IGF2BP3
Description
The IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3) is a protein-coding gene located on chromosome 7.
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is a protein encoded by the IGF2BP3 gene in humans. It is primarily found in the nucleolus, where it binds to the 5' UTR of the insulin-like growth factor II leader 3 mRNA, potentially repressing translation of insulin-like growth factor II during late development. IGF2BP3 contains several KH domains, crucial for RNA binding and involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, with putative pseudogenes on other chromosomes.
IGF2BP3 is an RNA-binding protein that can recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This process, known as 'caging', allows mRNA transport and temporary storage. IGF2BP3 modulates the rate and location at which target transcripts encounter the translational machinery, protecting them from endonucleases and microRNA-mediated degradation. It preferentially binds to N6-methyladenosine (m6A)-containing mRNAs, enhancing their stability. IGF2BP3 binds to the 3'-UTR of CD44 mRNA, stabilizing it and promoting cell adhesion and invadopodia formation in cancer cells. It also interacts with beta-actin/ACTB and MYC transcripts, increasing MYC mRNA stability by binding to the coding region instability determinant (CRD). This binding is enhanced by m6A modification of the CRD. IGF2BP3 also binds to the 5'-UTR of insulin-like growth factor 2 (IGF2) mRNAs.
IGF2BP3 is also known as CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3.
