IFRD1
Description
The IFRD1 (interferon related developmental regulator 1) is a protein-coding gene located on chromosome 7.
IFRD1, or Interferon-related developmental regulator 1, is a protein produced by the IFRD1 gene in humans. Its expression is highest in neutrophils, skeletal and heart muscle, the brain, and the pancreas. In rats and mice, the corresponding gene is called PC4 and Tis21, respectively. IFRD1 belongs to a gene family with a second member, IFRD2, also known as SKmc15.
IFRD1 has been identified as a modifier gene for cystic fibrosis lung disease. The type of IFRD1 polymorphism present in an individual influences neutrophil effector function. Data from humans and mice suggest that IFRD1 significantly impacts cystic fibrosis development by regulating neutrophil effector function.
IFRD1 (also known as PC4 or Tis7) is involved in skeletal muscle cell differentiation. Inhibiting IFRD1 activity in C2C12 myoblasts, either by using antisense IFRD1 cDNA transfection or by microinjecting anti-IFRD1 antibodies, prevents their morphological and biochemical differentiation by suppressing the expression of MyoD and myogenin, key regulators of muscle development. A similar role for IFRD1 in muscle differentiation has also been observed in vivo.
IFRD1 might influence gene regulation within cell growth and differentiation processes triggered by nerve growth factor (NGF). It could act as an autocrine factor, either decreasing or enhancing the initial signal initiated by NGF binding.
IFRD1 is also known as PC4, TIS7.
