IER5
Description
The IER5 (immediate early response 5) is a protein-coding gene located on chromosome 1.
IER5, or Immediate early response gene 5 protein, plays a role as a transcription factor. It mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner and mediates negative transcriptional regulation of CDC25B expression. It is involved in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. IER5 is involved in the regulation of cell proliferation and resistance to thermal stress. It is also involved in the cell cycle checkpoint and survival in response to ionizing radiation. It associates with chromatin to the CDC25B promoter. IER5 can exist as a monomer or a homodimer. It interacts with the catalytic subunit of protein phosphatase PP2A, as well as with PPP2R2B, PPP2R2A, PPP2R2C, and PPP2R2D. It also interacts with RPS6KB1 and HSF1.
IER5 is involved in the regulation of cell proliferation, resistance to thermal stress, and cell cycle checkpoint, as well as survival in response to ionizing radiation. It is a transcription factor that positively regulates the expression of chaperone genes during heat shock and negatively regulates CDC25B expression. It also plays a role in the dephosphorylation of HSF1 and S6K by the protein phosphatase PP2A. IER5 interacts with the catalytic subunit of PP2A, as well as with PPP2R2B, PPP2R2A, PPP2R2C, and PPP2R2D. It also interacts with RPS6KB1 and HSF1, promoting the dephosphorylation of HSF1 and leading to enhanced HSF1 transcriptional activity.
IER5 is also known as SBBI48.
