IDE
Description
The IDE (insulin degrading enzyme) is a protein-coding gene located on chromosome 10.
IDE, iDE, or Ide may refer to:
IDE (Insulin-degrading enzyme) is a protease involved in the breakdown of various peptides, including insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, and kallidin. This breakdown plays a crucial role in intercellular peptide signaling. Substrate binding to IDE triggers conformational changes, enabling it to degrade larger substrates like insulin. IDE contributes to the regulation of peptide hormone signaling cascades and blood glucose homeostasis through its degradation of insulin, glucagon, and IAPP. It also participates in the degradation and clearance of amyloidogenic peptides derived from APP, which are secreted by neurons and microglia. IDE degrades the natriuretic peptides ANP, BNP, and CNP, inactivating their ability to elevate intracellular cGMP. It also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA), linked to familial atrial fibrillation in heterozygous individuals. IDE is involved in antigen processing, producing both the N-terminus and C-terminus of the MAGEA3-derived antigenic peptide (EVDPIGHLY), presented to cytotoxic T lymphocytes by MHC class I.
IDE is also known as INSULYSIN.
Associated Diseases
- type 2 diabetes mellitus
- asthma
- ovarian cancer
- esophageal cancer
- childhood onset asthma
- hyperinsulinism due to INSR deficiency
- hyperinsulinism due to glucokinase deficiency
- male infertility with teratozoospermia due to single gene mutation
- familial male-limited precocious puberty
- partial chromosome Y deletion
