ID4
Description
The ID4 (inhibitor of DNA binding 4) is a protein-coding gene located on chromosome 6.
ID4 is a protein coding gene that encodes the DNA-binding protein inhibitor ID-4. This protein plays a role in regulating many cellular processes during both prenatal development and tumorigenesis, including embryonic cellular growth, senescence, cellular differentiation, apoptosis, and angiogenesis. The gene spans 3.3kb on the plus strand and is composed of 3 exons. Its mRNA is 2343 bp and encodes a 161 amino acid protein with a molecular weight of 16.6 KDa. The protein contains a poly-Ala segment from amino acid 39 to 48, a helix-loop-helix motif from amino acid 65 to 105, and a poly-Pro region from amino acid 118 to 124. ID4 is part of the ID gene family, which consists of transcription inhibitory proteins that modulate a number of cellular processes.
ID4 is a transcriptional regulator that lacks a basic DNA binding domain. It negatively regulates basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. This regulation is implicated in a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation.
ID4 is also known as IDB4, bHLHb27.
