HTN1
Description
The HTN1 (histatin 1) is a protein-coding gene located on chromosome 4.
Histatin-1 is a protein that in humans is encoded by the HTN1 gene.
Histatins (Hsts) are cationic and histidine-rich secreted peptides mainly synthesized by saliva glands of humans and higher primates. They are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). Hsts can be divided into two major groups according to their biological functions: antimicrobial Hsts (e.g. Hst 5/HTN3) and cell-activating Hsts (e.g. Hst 1/HTN1 and Hst 2/HTN1). Hst 1/HTN1 and Hst 2/HTN1 act in different cell types (epithelium, fibroblasts and endothelium) in oral and non-oral mucosa.
HTN1 is also known as HIS1, Hst1.
Associated Diseases
- endometrial cancer
- microphthalmia with limb anomalies
- cancer
- enamel caries
- glycogen storage disease VI
- periodontal disorder
- Huntington disease
