HOXB8
Description
The HOXB8 (homeobox B8) is a protein-coding gene located on chromosome 17.
HOXB8 is a gene that encodes a protein called Homeobox protein Hox-B8. This protein is a transcription factor, meaning it controls the activity of other genes. It belongs to the Antp homeobox family and has a DNA-binding domain, allowing it to bind to specific regions of DNA. HOXB8 is part of a cluster of genes located on chromosome 17. Increased expression of this gene is associated with colorectal cancer. Studies in mice have shown that HOXB8 is involved in regulating grooming behavior, and its absence can lead to compulsive grooming similar to trichotillomania in humans. Transplantation of normal bone marrow into a mouse lacking HOXB8 reduces this compulsive grooming behavior.
HOXB8 is also known as HOX2, HOX2D, Hox-2.4.
Associated Diseases
- autosomal recessive spondylocostal dysostosis
- pachyonychia congenita
- autosomal dominant spondylocostal dysostosis
- thoracolaryngopelvic dysplasia
- thoracomelic dysplasia
- spondylometaphyseal dysplasia, A4 type
- short-rib thoracic dysplasia 17 with or without polydactyly
- spondylometaphyseal dysplasia, Kozlowski type
- spondyloepimetaphyseal dysplasia, matrilin-3 type
- kyphomelic dysplasia
- mesomelic dysplasia, Kantaputra type
- spondyloepimetaphyseal dysplasia, Missouri type
- Becker nevus syndrome
- fibrochondrogenesis 2
- spondyloepimetaphyseal dysplasia, Irapa type
- Dyggve-Melchior-Clausen disease
