HOXA3
Description
The HOXA3 (homeobox A3) is a protein-coding gene located on chromosome 7.
HOXA3 is a human gene that encodes the homeobox protein Hox-A3. It is a transcription factor, a protein that binds to DNA and regulates the expression of other genes. HOXA3 is part of a family of genes called homeobox genes, which are essential for proper embryonic development. HOXA3 is expressed in specific cells during fetal development, including the neural crest cells and endodermal cells of the third pharyngeal pouch. It plays a crucial role in the formation of the thymus, thyroid, and parathyroid glands. Mutations in HOXA3 can lead to developmental defects in these organs, including athymia (absence of the thymus) and aparthyroidism (absence of the parathyroid glands).
HOXA3 is also known as HOX1, HOX1E.
