HNRNPR
Description
The HNRNPR (heterogeneous nuclear ribonucleoprotein R) is a protein-coding gene located on chromosome 1.
HNRNPR is a protein encoded by the HNRNPR gene in humans. It belongs to the family of hnRNPs, which are RNA-binding proteins that complex with hnRNA in the nucleus. HNRNPR is involved in pre-mRNA processing and other aspects of mRNA metabolism and transport. It shuttles between the nucleus and cytoplasm and has three repeats of RRM domains for RNA binding, along with a nuclear localization motif. Specifically, HNRNPR is crucial for axonal growth in motoneurons, working with 7SK to facilitate this development. It binds to the 3'-UTR of β-actin mRNA, facilitating its translocation in axons. Additionally, HNRNPR enhances c-fos transcription by interacting with PC4 and Mediator cofactors.
HNRNPR is also known as HNRPR, NEDDFSB, hnRNP-R.
