HNF4G
Description
The HNF4G (hepatocyte nuclear factor 4 gamma) is a protein-coding gene located on chromosome 8.
Hepatocyte nuclear factor 4 gamma (HNF4G), also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2), is a nuclear receptor that in humans is encoded by the HNF4G gene. HNF4G is a transcription factor that has been shown to play a significant role in intestinal epithelial cell differentiation and function. Research using integrative multi-omics analysis of intestinal organoid differentiation has revealed that HNF4G acts as a master regulator of gene regulation in differentiation towards the enterocyte lineage. The study demonstrated widespread binding to promoters and enhancers that are activated in enterocytes, and that the loss of Hnf4g results in a partial loss of enterocyte differentiation, indicating its importance in maintaining the enterocyte lineage.
HNF4G is also known as NR2A2, NR2A3.
Associated Diseases
- specific developmental disorder
- lysosomal storage disease
- Alzheimer disease
- Parkinson disease
- multiple sclerosis
