HN1L
Huntington's Disease (HD)
Description
Huntington's disease (HD) is a progressive, inherited neurological disorder that affects movement, cognition, and behavior. It is caused by a mutation in the HTT gene, which results in the production of a toxic protein called huntingtin. This protein aggregates in the brain, leading to neuronal damage and dysfunction.
HD typically manifests in adulthood, usually between 30 and 50 years of age. Symptoms can vary widely, but commonly include:
- Involuntary movements (chorea)
- Muscle rigidity
- Balance problems
- Dementia
- Depression
- Personality changes
Associated Diseases
HD is not typically associated with other specific diseases, but it can increase the risk of certain conditions, such as:
- Psychiatric disorders
- Cardiovascular disease
- Diabetes
- Pneumonia
Did you Know ?
Approximately 1 in 10,000 people worldwide have HD.
