HMSD
Description
The HMSD (histocompatibility minor serpin domain containing) is a protein-coding gene located on chromosome 18.
HMSD, also known as ACC-6, is a minor histocompatibility antigen (mHag) that can trigger immune responses in the context of transplantation. It is a splice variant of the HMSD gene and functions as a precursor protein. mHags are polymorphic peptides that bind to MHC molecules and can elicit T-cell responses. In the context of hematopoietic stem cell transplantation (HSCT) from HLA-identical sibling donors, mismatches in mHags can lead to graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL). ACC-6 specifically interacts with MHC HLA-B4403, leading to donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after HLA-identical allogenic HSCT. The interaction with HLA-B4403 promotes cell recognition and lysis by CTLs. The immunogenicity of HMSD, like most other autosomal mHags, stems from single-nucleotide polymorphisms that cause amino-acid substitutions within epitopes, leading to differential recognition of peptides between donor and recipient.
HMSD is also known as ACC-6, ACC6, C18orf53, HSMD-v.
