HLA-J
Description
The HLA-J (major histocompatibility complex, class I, J (pseudogene)) is a pseudo gene located on chromosome 6.
HLA-J is a non-classical major histocompatibility complex (MHC) class I molecule that is involved in immune regulation. It is expressed on a variety of cells and has been shown to bind peptides and interact with various immune cells, including natural killer (NK) cells and T cells. HLA-J has been suggested to contribute to immune tolerance and may play a role in viral evasion.
HLA-J is a non-classical major histocompatibility complex (MHC) class I molecule that plays a role in immune regulation and viral evasion. It has been shown to bind peptides and interact with various immune cells, including natural killer (NK) cells and T cells. HLA-J is expressed on a variety of cells, including dendritic cells, B cells, and epithelial cells, and its expression can be modulated by various stimuli. It has been suggested that HLA-J may contribute to immune tolerance by presenting peptides to NK cells and inhibiting their activation. Additionally, HLA-J has been implicated in viral evasion, as some viruses can exploit HLA-J to evade immune recognition. Furthermore, HLA-J has been linked to several autoimmune diseases, including systemic lupus erythematosus (SLE).
HLA-J is also known as CDA12, D6S203, HLA-59, HLA-CDA12.
