HLA-DOB
Description
The HLA-DOB (major histocompatibility complex, class II, DO beta) is a protein-coding gene located on chromosome 6.
HLA class II histocompatibility antigen, DO beta chain is a protein encoded by the HLA-DOB gene in humans. It belongs to the HLA class II beta chain paralogues, forming a heterodimer with an alpha chain (DOA) and a beta chain (DOB). This complex is located within intracellular vesicles and plays a role in suppressing peptide loading of MHC class II molecules by inhibiting HLA-DM. HLA-DM is involved in the antigen presentation pathway, which occurs in antigen-presenting cells (APCs) such as B lymphocytes, dendritic cells, and macrophages. The beta chain has a molecular weight of approximately 26-28 kDa and its gene comprises 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain, and exon 5 encodes the cytoplasmic tail.
HLA-DOB, also known as MHC class II antigen DOB, is a key modulator in the HLA class II restricted antigen presentation pathway within B-cells. It directly interacts with the HLA-DM molecule, influencing its peptide exchange activity.
HLA-DOB is also known as DOB, HLA_DOB.
