HLA-DOA
Description
The HLA-DOA (major histocompatibility complex, class II, DO alpha) is a protein-coding gene located on chromosome 6.
HLA-DOA, also known as HLA class II histocompatibility antigen, DO alpha chain, is a protein encoded by the HLA-DOA gene. It belongs to the HLA class II alpha chain paralogues and forms a heterodimer with HLA-DOB. This heterodimer, HLA-DO, is found in lysosomes within B cells and plays a regulatory role in peptide loading on MHC class II molecules by interacting with HLA-DM. Compared to classical HLA class II molecules, HLA-DOA shows very limited sequence variation, especially at the protein level.
HLA-DOA, also known as MHC DN-alpha, MHC DZ alpha, and MHC class II antigen DOA, is a crucial modulator in the HLA class II restricted antigen presentation pathway. It interacts with the HLA-DM molecule in B cells, modifying the peptide exchange activity of HLA-DM.
HLA-DOA is also known as HLA-DNA, HLA-DZA, HLADZ.
Associated Diseases
- immune deficiency, familial variable
- hyper-IgM syndrome type 3
- hyper-IgM syndrome type 2
- hyper-IgM syndrome type 5
- immunodeficiency, common variable, 14
- classic Hodgkin lymphoma
- immunodeficiency, common variable, 7
- cancer
