HIVEP1
Description
The HIVEP1 (HIVEP zinc finger 1) is a protein-coding gene located on chromosome 6.
HIVEP1 (also known as Zinc finger protein 40) is a protein encoded by the HIVEP1 gene in humans. It belongs to the ZAS family, which are large proteins with a ZAS domain, a structure containing two C2H2 zinc fingers. These proteins bind specific DNA sequences, including the kappa-B motif, in the promoters and enhancer regions of various genes and viruses, such as HIV. HIVEP1 is a large gene spanning over 150 kb with at least 10 exons.
HIVEP1 binds to a specific DNA sequence (5'-GGGACTTTCC-3') found in the enhancer elements of many viral promoters, including those of SV40, CMV, and HIV-1. It also binds to similar sequences in the enhancer elements of several cellular promoters, such as those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. HIVEP1 may play a role in T-cell activation. Different isoforms of HIVEP1 have different functions: Isoform 2 and isoform 3 bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes, regulating their transcription. Isoform 2 does not activate HIV-1 gene expression, while isoforms 2 and 3 may be involved in apoptosis.
HIVEP1 is also known as CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A.
