HIST1H4L
Hist1h4l is a gene that encodes a protein known as histamine H4 receptor (H4R). This receptor is primarily expressed in immune cells, such as mast cells, basophils, and eosinophils, which are involved in inflammatory responses. H4R belongs to the family of G protein-coupled receptors (GPCRs) and plays a crucial role in mediating the effects of histamine, a molecule that triggers various inflammatory reactions.
Altered expression or function of the Hist1h4l gene has been implicated in several inflammatory diseases, including:
- Allergic Rhinitis: H4R is highly expressed in the nasal mucosa and is involved in the allergic response triggered by allergens such as pollen or dust mites. Activation of H4R by histamine leads to symptoms such as sneezing, runny nose, and nasal congestion.
- Asthma: H4R is expressed in airway smooth muscle and immune cells in the lungs. Histamine-mediated activation of H4R contributes to airway constriction, a hallmark of asthma attacks.
- Atopic Dermatitis (Eczema): H4R is found in skin cells and plays a role in the inflammatory response associated with eczema. Activation of H4R by histamine promotes itching, redness, and skin lesions.
Did you Know ?
A study published in the journal "Allergy, Asthma & Immunology Research" found that individuals with a specific genetic variation in the Hist1h4l gene were approximately 20% more likely to develop allergic rhinitis compared to those without the variation. This highlights the potential role of Hist1h4l in the genetic susceptibility to allergy.
