HIST1H4F
Histone 1H4F: A Key Player in Epigenetics and Disease
Description:
Histone 1H4F is a fundamental protein that plays a crucial role in epigenetics, the study of how heritable changes can occur in gene expression without altering the underlying DNA sequence. Histones are proteins that package DNA into structures called nucleosomes, which regulate gene accessibility and expression. Histone 1H4F is specifically associated with transcriptionally active regions of the genome.
Associated Diseases:
Alterations in histone 1H4F have been linked to several human diseases, including:
- Cancer: Histone 1H4F is deregulated in various cancers, including breast, prostate, and lung cancer. Overexpression of 1H4F has been associated with increased cell growth, tumor formation, and metastasis.
- Developmental disorders: Mutations in the HIST1H4F gene have been linked to intellectual disability, autism spectrum disorder, and congenital heart defects.
- Neurological disorders: Abnormal 1H4F expression has been observed in neurodegenerative diseases such as Alzheimer's disease and Huntington's disease.
Did you Know ?
Research suggests that approximately 2% of the human population carries genetic variants in the HIST1H4F gene that may increase their susceptibility to certain diseases.
