HIST1H3G
Human Histone 1H3G: A Vital Chromatin Component with Diverse Roles
Description:
Human histone 1H3G is a small, highly conserved protein that plays a crucial role in the structure and function of chromatin, the material that makes up chromosomes. Histones are proteins that package DNA into compact units called nucleosomes, which are the building blocks of chromatin. Histone 1H3G is one of the five main histone proteins (H1, H2A, H2B, H3, and H4) found in eukaryotic cells.
Associated Diseases:
Mutations or dysregulation of histone 1H3G have been linked to several diseases, including:
- Glioblastoma: A highly aggressive brain cancer that is characterized by rapid growth and poor prognosis.
- Pancreatic cancer: A cancer of the pancreas that is often difficult to diagnose and treat.
- Acute myeloid leukemia: A type of blood cancer that affects the bone marrow and blood.
- Other cancers: Histone 1H3G alterations have been implicated in various other cancers, including breast cancer, prostate cancer, and lung cancer.
Did you Know ?
Studies have shown that altered levels of histone 1H3G can be detected in the blood of patients with certain types of cancer, making it a potential biomarker for early detection.
