HIST1H2BO
Hist1h2bo: Unraveling the Enigma of a Key Histone Modifier
Description
Hist1h2bo, also known as histone H2B type 1-O, is a vital protein involved in regulating gene expression. As an integral component of the nucleosome, the fundamental unit of chromatin, Hist1h2bo plays a crucial role in guiding gene-specific transcription. It achieves this regulation through its ability to alter the chromatin structure, influencing accessibility of DNA to transcription machinery.
Associated Diseases
Aberrant expression or mutations in Hist1h2bo have been implicated in various diseases, including:
- Cancer: Hist1h2bo overexpression is commonly observed in a range of malignancies, such as breast, prostate, and lung cancer. This overexpression is associated with increased cell proliferation, invasion, and metastasis.
- Neurological disorders: Dysregulation of Hist1h2bo has been linked to neurodegenerative diseases like Alzheimer's disease and Huntington's disease. Its abnormal expression can lead to neuronal toxicity and impaired cognitive function.
- Developmental disorders: Mutations in Hist1h2bo have been linked to developmental abnormalities in humans and animal models. These mutations can result in impaired embryologic development and various disease manifestations.
Did you Know ?
A comprehensive study of over 2,000 cancer genomes revealed that Hist1h2bo overexpression was present in approximately 30% of cases, highlighting its potential significance as a therapeutic target.
