HIST1H2BM
Histone 1H2B: A Molecular Enigma
Description:
Histone 1H2B is a highly conserved eukaryotic protein that plays a crucial role in DNA packaging and gene regulation. It is one of the five core histones that form the nucleosome, the basic unit of chromatin that packages DNA into a highly organized structure within the nucleus. 1H2B is responsible for maintaining the stability and accessibility of chromatin, allowing cells to efficiently access genetic information.
Associated Diseases:
Mutations and abnormalities in 1H2B have been linked to several human diseases, including:
- Cancer: 1H2B mutations have been implicated in the development of various cancers, such as colorectal cancer, breast cancer, and lung cancer. These mutations can disrupt the normal function of 1H2B in chromatin regulation, leading to uncontrolled cell growth and proliferation.
- Neurological disorders: Alterations in 1H2B have also been associated with neurological disorders, such as autism spectrum disorder (ASD) and intellectual disability. These changes can affect the brain's ability to regulate gene expression and neuronal development.
- Cardiovascular diseases: 1H2B modifications have been found to play a role in cardiovascular diseases, such as atherosclerosis. Dysregulation of 1H2B can contribute to the formation of atherosclerotic plaques and the development of cardiovascular events.
Did you Know ?
- In a study published in the journal Nature, researchers found that a mutation in the 1H2B gene was present in approximately 2% of patients with colorectal cancer.
