HIST1H1D
Hist1h1d: A Comprehensive Overview
Description
Hist1h1d, also known as histamine H1 receptor D, is a protein that belongs to the histamine receptor family. Histamine is a neurotransmitter and signaling molecule that plays crucial roles in various physiological processes, including immune responses, inflammation, and neurotransmission. The Hist1h1d receptor specifically binds to histamine and mediates its effects.
Associated Diseases
Mutations or dysregulation of Hist1h1d have been linked to several diseases and conditions, including:
- Allergic Diseases: Hist1h1d is involved in allergic reactions, such as allergic rhinitis (hay fever) and asthma. It mediates the release of histamine from mast cells, which triggers inflammation and symptoms like sneezing, runny nose, and difficulty breathing.
- Inflammatory Diseases: Hist1h1d plays a role in chronic inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. It contributes to the recruitment of immune cells and the release of inflammatory mediators.
- Neurological Disorders: Hist1h1d is present in the central nervous system and may be involved in neurological disorders like epilepsy and schizophrenia. Studies suggest that it influences neuronal excitability and neurotransmitter release.
Did you Know ?
Approximately 10-20% of the global population carries genetic variations in the Hist1h1d gene, which can impact its function and contribute to disease susceptibility.
