STEAP3

Description

The STEAP3 (STEAP3 metalloreductase) is a protein-coding gene located on chromosome 2.

STEAP3 is a metalloreductase enzyme encoded by the STEAP3 gene in humans. It converts insoluble ferric iron (Fe3+) to soluble ferrous iron (Fe2+). STEAP3 and other STEAP proteins, except STEAP1, are predicted to have a Di-nucleotide binding domain (Rossmann Fold), confirmed by X-ray crystallography for STEAP3 and STEAP4. STEAP3 interacts with BNIP3L and PKMYT1.

STEAP3 is an integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. It mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate. STEAP3 can also reduce Cu(2+) to Cu(1+). It mediates efficient transferrin-dependent iron uptake in erythroid cells. STEAP3 may play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. It is indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.

STEAP3 is also known as AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde.

Associated Diseases

• Severe congenital hypochromic anemia with ringed sideroblasts
• Anemia, hypochromic microcytic, with iron overload 2