SRP54
Description
The SRP54 (signal recognition particle 54) is a protein-coding gene located on chromosome 14.
SRP54 is a protein that is part of the signal recognition particle (SRP) complex. The SRP is a complex of proteins and RNA that helps to direct newly made proteins to the endoplasmic reticulum (ER), where they are folded and processed. SRP54 binds to the signal sequence of a protein as it is being made, and then helps to guide the protein to the ER. SRP54 also interacts with the SRP receptor (SR) on the ER membrane, which helps to dock the SRP complex to the ER. Once the protein is delivered to the ER, it is translocated across the ER membrane and begins to fold into its correct three-dimensional structure. SRP54 is essential for the proper targeting and folding of proteins, and its dysfunction can lead to a variety of diseases.
SRP54 is a component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that directs the movement of newly synthesized secretory and membrane proteins to the endoplasmic reticulum (ER). It associates with the SRP receptor (SR) component SRPRA to target these proteins to the ER membrane. SRP54 binds to the signal sequence of nascent proteins as they emerge from ribosomes and displays basal GTPase activity, stimulating reciprocal GTPase activation of SRPRA. This interaction forms a GTP-dependent complex that leads to SR compaction and GTPase-mediated rearrangement, facilitating the translocation of proteins into the ER. SRP54 requires the presence of SRP9/SRP14 and/or SRP19 for stable RNA interactions. It also plays a role in the proliferation and differentiation of granulocytic cells, neutrophil migration, and exocrine pancreas development.
SRP54 is also known as SCN8.
