RBM8A : RNA binding motif protein 8A
Description
The RBM8A (RNA binding motif protein 8A) is a protein-coding gene located on chromosome 1.
The RBM8A gene instructs the production of RNA-binding motif protein 8A, which is believed to be involved in several crucial cellular processes related to protein production. These functions include assisting in the transport of mRNA molecules, the genetic blueprints for protein synthesis, from the nucleus to protein assembly sites. RBM8A might also regulate how mRNA instructions are used to build proteins and contribute to the degradation of faulty or unnecessary mRNA.
RBM8A is essential for pre-mRNA splicing, functioning as a component of the spliceosome. It is a core part of the exon junction complex (EJC), a multiprotein assembly that marks splice junctions on mRNAs. The EJC plays a crucial role in regulating various aspects of mRNA metabolism, including nuclear export, subcellular localization, translation efficiency, and nonsense-mediated decay (NMD). RBM8A, as part of the MAGOH-RBM8A heterodimer, stabilizes the EJC on spliced mRNA by inhibiting the ATPase activity of EIF4A3. This heterodimer also interacts with PYM1, leading to EJC disassembly in the cytoplasm and promoting translation by recruiting EJC-bearing mRNAs to the ribosome. RBM8A preferentially associates with spliced mRNAs and participates in the NMD pathway. It also influences the splicing of apoptotic genes, specifically inhibiting the formation of proapoptotic isoforms.
RBM8A is also known as BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1.
