TPI1 : triosephosphate isomerase 1
Description
The TPI1 (triosephosphate isomerase 1) is a protein-coding gene located on chromosome 12.
The TPI1 gene provides instructions for making the enzyme triosephosphate isomerase 1. This enzyme is essential for glycolysis, the process that breaks down glucose to produce energy for cells. Triosephosphate isomerase 1 converts dihydroxyacetone phosphate (DHAP) to glyceraldehyde 3-phosphate, a step that can occur in both directions. For the enzyme to be active, it needs to bind to another triosephosphate isomerase 1 enzyme, forming a two-enzyme complex called a dimer.
Triosephosphate isomerase 1 (TPI1) is a highly efficient metabolic enzyme that plays a crucial role in both glycolysis and gluconeogenesis. It catalyzes the reversible conversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P), which are essential intermediates in these pathways.
TPI1 is also known as HEL-S-49, TIM, TPI, TPID.
