HTRA2

Description

The HTRA2 gene encodes a serine protease, also known as Omi/HtrA2, which plays a crucial role in regulating the extracellular matrix (ECM) by degrading various proteins. It exhibits diverse functions, including the regulation of apoptosis, inflammation, and cellular stress responses. HTRA2 is involved in several cellular processes, including protein quality control, proteolytic processing, and the maintenance of cellular homeostasis.

Associated Diseases

• Alzheimer‘s disease
• Cancer (e.g., breast, lung, colorectal)
• Neurodegenerative disorders
• Cardiovascular diseases
• Inflammatory bowel disease

Did you know?

HTRA2 is a highly conserved protein, with homologs found in various organisms, suggesting its critical role in biological processes.